Thematic review series: The Immune System and Atherogenesis. Immune function in atherogenesis

Thematic review series: The immune system and atherogenesis. Cytokine regulation of macrophage functions in atherogenesis.

This review will focus on the role of cytokines in the behavior of macrophages, a prominent cell type of atherosclerotic lesions. Once these macrophages have immigrated into the vessel wall, they propagate the development of atherosclerosis by modifying lipoproteins, accumulating intracellular lipids, remodeling the extracellular environment, and promoting local coagulation. The numerous cytoki...

Modeling immune system control of atherogenesis

MOTIVATION Atherosclerosis is a disease that is present in almost all humans, typically beginning in early adolescence. It is a human disease broadly investigated, that is amenable to quantitative analysis. Oxidized low-density lipoproteins (LDLs) and their autoantibodies are involved in the development of atherosclerosis in animal models, but their role in humans is still not clear. Computer m...

Promise of immune modulation to inhibit atherogenesis.

t is now widely recognized that the evolving atherosclerotic esion has nearly all of the characteristics of a chronic nflammatory disease, including the active participation of any arcs of immune function. That immune mechanisms lay an important, if not dominant, role once atherosclerosis as been initiated is attested to by scores of examples in hich manipulations of both adaptive and innate im...

Dendritic Cells in Atherogenesis: From Immune Shapers to Therapeutic Targets

Nutrition and platelet function in atherogenesis.

Platelets are undoubtedly involved in the final occlusion of atheromatous arteries forming the major component of the occlusive thrombus (Davies & Thomas, 1981). This sudden and often catastrophic event is most likely precipitated by fissuring of an atheromatous plaque, as detailed post-mortem analysis of obstructed coronary arteries invariably shows the thrombus in association with plaque haem...